Molecular Formula | C28H39ClN2O4 |
Molar Mass | 503.08 |
Appearance | neat |
Storage Condition | 2-8℃ |
Physical and Chemical Properties | White to yellow powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from ipecac, angola octagonal maple. |
In vitro study | CYP2D6 reveals the highest metabolic activity for the generation of 9-O-demethylEmetine, whereas this enzyme also shows a significant metabolic activity for the generation of Cephaeline. The IC 50 s of Cephaeline against CYP2C9, CYP2D6 and CYP3A4 is over 1000, 121 and 1000 μM, respectively. Further experiments are performed to determine inhibition constants (K i ) for Cephaeline on the CYP2D6 and CYP3A4 activities Graphic analysis of Dixon plots at various Cephaeline concentrations for each of the two CYP enzyme assays yield K i s of 54 and 355 μM for CYP2D6 and CYP3A4, respectively. |
UN IDs | 1544 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 oral in mouse: 74970ug/kg |
1mg | 5mg | 10mg | |
---|---|---|---|
1 mM | 1.853 ml | 9.267 ml | 18.534 ml |
5 mM | 0.371 ml | 1.853 ml | 3.707 ml |
10 mM | 0.185 ml | 0.927 ml | 1.853 ml |
5 mM | 0.037 ml | 0.185 ml | 0.371 ml |